Single-nucleotide polymorphisms among microRNA: big effects on cancer
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چکیده
منابع مشابه
Single-nucleotide polymorphisms among microRNA: big effects on cancer
MicroRNAs (miRNAs) are small non-coding RNAs that regulate gene expression at the transcriptional or posttranscriptional level. Many miRNAs are found to play a significant role in cancer development either as tumor suppressor genes or as oncogenes. Examination of tumor-specific miRNA expression profiles in diverse cancers has revealed widespread deregulation of these molecules, whose loss and o...
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Gastric cancer is the second most frequent cause of cancer-related deaths worldwide. MicroRNAs (miRNAs) are a novel class of endogenous noncoding regulatory sequences that interact with tumor oncogenes and suppressors. Many studies have indicated that single-nucleotide polymorphisms (SNPs) in miRNAs influence the susceptibility of gastric cancer. MiRNA SNPs have been explored for several years ...
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Since the discovery of microRNA (miRNA), the polymorphisms that affect miRNA regulation had been extensively investigated by many independent studies. Recently, researchers utilized bioinformatics and statistical approaches for genome-wide analysis on the human polymorphisms that reside in the miRNA genes, targets, and/or genes involved in miRNA processing. In this review, we will give an overv...
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ژورنال
عنوان ژورنال: Chinese Journal of Cancer
سال: 2011
ISSN: 1000-467X,1944-446X
DOI: 10.5732/cjc.011.10142